2-Methoxyestradiol: A Potential Treatment for Multiple Proliferative Disorders
نویسندگان
چکیده
منابع مشابه
Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma.
PURPOSE 2-Methoxyestradiol (2ME2) is an endogenous product of estradiol metabolism with antiangiogenic and antineoplastic properties. We report on the first phase II trial of 2ME2 in multiple myeloma. EXPERIMENTAL DESIGN 2ME2 was administered orally at a dose of 1,000 mg daily. Sixty patients (31 men and 29 women) were treated. After 39 patients were accrued, the dose was increased to 800 mg ...
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To the Editor: We disagree with the conclusions in a recent article by Sutherland et al. (1) stating that 2-methoxyestradiol (2ME2) is an unsuitable antitumor agent that lacks efficacy and has estrogen receptor–dependent and estrogen receptor– independent adverse effects. Although the data reported in this article are interesting, it is inappropriate to conclude that 2ME2 is unsuitable as an an...
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2-Methoxyestradiol (2ME2) an estrogen derivative, induces growth arrest and apoptosis in leukemic cells and is also antiangiogenic. In this study, we demonstrate that 2ME2 inhibits growth and induces apoptosis in multiple myeloma (MM) cell lines and patient cells. Significantly, 2ME2 also inhibits growth and induces apoptosis in MM cells resistant to conventional therapies including melphalan (...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2007
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2007-0514